Osteoarthritis is the most common form of arthritis and often occurs in the hands, feet, hips, knees, and spine. There is no cure.
The disease affects more than 500 million people worldwide, according to the 2019 Global Burden of Disease study, and disproportionately affects women. It is a leading cause of disability due to the severe pain it can cause.
People develop osteoarthritis when the protective cartilage that cushions the bones in their joints begins to break down, causing them to rub together.
The study uncovered "high-value drug targets" for potential treatments. A so-called drug target is a molecule in the body linked to how a disease process plays out and could be altered using a drug. Such targets are important in helping to stop disease progression in the body.
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