Scientists have uncovered evidence of the oldest known plague outbreaks in human history, identifying infections that occurred approximately 5,500 years ago among hunter-gatherer communities living near Lake Baikal.
The findings, published in the journal Nature, significantly reshape understanding of when and how devastating epidemics first emerged.
The new study challenges that assumption by showing that plague affected relatively small hunter-gatherer groups thousands of years before farming became widespread in many regions.
The research team analyzed genetic material from 42 ancient individuals and detected DNA from the plague-causing bacterium, Yersinia pestis, in 18 of them.
Evidence suggests that local marmot populations may have served as the original animal reservoir, transmitting the pathogen to humans. Researchers found signs that children were particularly vulnerable during the outbreak.
Archaeological evidence indicates the disease spread rapidly through affected communities. Mass burials and patterns of mortality suggest a severe epidemic that may have devastated entire groups.
Scientists described the outbreak as one of the earliest known examples of a highly lethal infectious disease affecting human populations on a significant scale.
Beyond its implications for human history, the discovery also sheds light on the evolution of the plague bacterium itself.
Researchers say the findings reveal previously unknown genetic diversity and provide an unprecedented glimpse into the earliest stages of one of history's most notorious pathogens.
The study offers new insight into how infectious diseases shaped prehistoric societies and suggests that epidemic outbreaks may have influenced human communities long before the emergence of cities, agriculture, and complex civilizations.
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The oldest-known traces of plague, around 5,500 years old, have been discovered in hunter-gatherer burials in Siberia.https://t.co/8tD6VezaU6
— Science News (@ScienceNews) June 17, 2026
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